AJP - Endo AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 255: E397-E402, 1988;
0193-1849/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Max, S. R.
Right arrow Articles by Vitkovic, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Max, S. R.
Right arrow Articles by Vitkovic, L.

AJP - Endocrinology and Metabolism, Vol 255, Issue 3 E397-E402, Copyright © 1988 by American Physiological Society

ARTICLES

Dexamethasone regulates glutamine synthetase expression in rat skeletal muscles

S. R. Max, J. Mill, K. Mearow, M. Konagaya, Y. Konagaya, J. W. Thomas, C. Banner and L. Vitkovic
Department of Neurology, University of Maryland School of Medicine, Baltimore 21201.

The regulation of glutamine synthetase expression by dexamethasone was studied in rat skeletal muscles. Daily administration of dexamethasone caused striking enhancement of glutamine synthetase activity in plantaris, soleus, and diaphragm muscles. Northern blot analysis revealed that the dexamethasone-mediated increase of glutamine synthetase activity was associated with dramatically increased levels of glutamine synthetase mRNA. Both glutamine synthetase activity and mRNA levels were significantly elevated in plantaris muscle at 0.5 mg.kg-1.day-1 of dexamethasone, a dose that approximates endogenous corticosteroid levels in animals under severe stress. Quantification of changes in glutamine synthetase mRNA on the basis of total mRNA (by oligo dT hybridization) also revealed a major increase in glutamine synthetase mRNA. Dexamethasone was without effect on beta-tubulin mRNA levels, indicating that glutamine synthetase induction is not part of a global response to glucocorticoids. Dexamethasone treatment resulted in only an approximately 15% increase in glutamine synthetase activity in heart; there was no change in glutamine synthetase mRNA level in this tissue. Thus glucocorticoids regulate glutamine synthetase gene expression in rat skeletal muscles.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
L. G. Menezes, C. Sobreira, L. Neder, A. L. Rodrigues-Junior, and J. A. Baddini Martinez
Creatine supplementation attenuates corticosteroid-induced muscle wasting and impairment of exercise performance in rats
J Appl Physiol, February 1, 2007; 102(2): 698 - 703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. M. Karinch, C.-M. Lin, Q. Meng, M. Pan, and W. W. Souba
Glucocorticoids have a role in renal cortical expression of the SNAT3 glutamine transporter during chronic metabolic acidosis
Am J Physiol Renal Physiol, January 1, 2007; 292(1): F448 - F455.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Verdier, Y. Boirie, S. Van Drieesche, M. Mignon, R.-J. Begue, and D. Meynial-Denis
Do sex steroids regulate glutamine synthesis with age?
Am J Physiol Endocrinol Metab, January 1, 2002; 282(1): E215 - E221.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
O. Le Bacquer, H. Nazih, H. Blottiere, D. Meynial-Denis, C. Laboisse, and D. Darmaun
Effects of glutamine deprivation on protein synthesis in a model of human enterocytes in culture
Am J Physiol Gastrointest Liver Physiol, December 1, 2001; 281(6): G1340 - G1347.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
P. Newsholme
Why Is L-Glutamine Metabolism Important to Cells of the Immune System in Health, Postinjury, Surgery or Infection?
J. Nutr., September 1, 2001; 131(9): 2515S - 2522.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
D. W. Wilmore
The Effect of Glutamine Supplementation in Patients Following Elective Surgery and Accidental Injury
J. Nutr., September 1, 2001; 131(9): 2543S - 2549.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. I. Labow, W. W. Souba, and S. F. Abcouwer
Glutamine synthetase expression in muscle is regulated by transcriptional and posttranscriptional mechanisms
Am J Physiol Endocrinol Metab, June 1, 1999; 276(6): E1136 - E1145.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. Minet-Quinard, C. Moinard, F. Villie, S. Walrand, M.-P. Vasson, J. Chopineau, and L. Cynober
Kinetic impairment of nitrogen and muscle glutamine metabolisms in old glucocorticoid-treated rats
Am J Physiol Endocrinol Metab, March 1, 1999; 276(3): E558 - E564.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y.-N. Sun, L. I. McKay, D. C. DuBois, W. J. Jusko, and R. R. Almon
Pharmacokinetic/Pharmacodynamic Models for Corticosteroid Receptor Down-Regulation and Glutamine Synthetase Induction in Rat Skeletal Muscle by a Receptor/Gene-Mediated Mechanism
J. Pharmacol. Exp. Ther., February 1, 1999; 288(2): 720 - 728.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online