AJP - Endo AJP: Advances in Physiology Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 254: E749-E755, 1988;
0193-1849/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pillion, D. J.
Right arrow Articles by Grizzle, W. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pillion, D. J.
Right arrow Articles by Grizzle, W. E.

AJP - Endocrinology and Metabolism, Vol 254, Issue 6 E749-E755, Copyright © 1988 by American Physiological Society

ARTICLES

Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats

D. J. Pillion, R. L. Jenkins, J. A. Atchison, C. R. Stockard, R. S. Clements Jr and W. E. Grizzle
Department of Pharmacology, University of Alabama, Birmingham 35294.

Adult male Fisher rats injected with streptozotocin (Stz) to produce diabetes mellitus demonstrated a significant loss of total body weight associated with adipose and muscle tissue wasting. Paradoxically, intestinal mass and length were increased in Stz-treated rats despite catabolism of other tissues. Concomitant with increased intestinal mass, food and water intake increased significantly in Stz-diabetic animals. Renal weight was not reduced despite the fall in total body weight. It is proposed that the adult Stz-diabetic rat responds to a loss of available insulin by polyphagia, polydipsia, and catabolism of adipose and muscle tissue and that a large percentage of available synthetic fuel is devoted to the production of additional intestinal tissue.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. D. Fischer, S. Dhanvantari, D. J. Drucker, and P. L. Brubaker
Intestinal growth is associated with elevated levels of glucagon-like peptide 2 in diabetic rats
Am J Physiol Endocrinol Metab, October 1, 1997; 273(4): E815 - E820.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online