AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 254: E625-E632, 1988;
0193-1849/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Diamond, P.
Right arrow Articles by LeBlanc, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Diamond, P.
Right arrow Articles by LeBlanc, J.

AJP - Endocrinology and Metabolism, Vol 254, Issue 5 E625-E632, Copyright © 1988 by American Physiological Society

ARTICLES

A role for insulin in cephalic phase of postprandial thermogenesis in dogs

P. Diamond and J. LeBlanc
Department of Physiology, School of Medicine, Laval University, Quebec City, Canada.

The influence of insulin in the cephalic phase of postprandial thermogenesis was investigated in dogs. O2 consumption (VO2) and respiratory quotient (RQ) were continuously monitored 1 h before and 2 h after a 1,015-kcal meal during a control, an atropine, or a pancreatic-denervation experiment. A first phase (cephalic phase) in VO2 increase, lasting at least 50 min, followed by a second phase (digestive phase) were found in the control experiment. During both the atropine and pancreatic-denervation experiment, the first phase of VO2 was inhibited by 52%. The second phase was completely abolished with atropine, whereas it remained comparable to the control in the case of pancreatic denervation. A peak increase for insulin (70 microU/ml over 0 time) was observed 2 min after the onset of feeding in control. It was followed after 25 min by a second increase related to changes in glycemia. Maximal rises of norepinephrine (NE) and epinephrine corresponded to 215 and 120 pg/ml above basal values at 2 min in control experiment. During both atropine and pancreatic denervation the cephalic phase of insulin release was suppressed and the NE increase was inhibited by congruent to 65%. During the digestive phase pancreatic denervation caused an increase in plasma insulin comparable to that of the control, whereas atropine produced no such effect. It is suggested that the cephalic phase of postprandial thermogenesis is mediated through a causal relationship between insulin and NE release.


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
P. J. Havel
Peripheral Signals Conveying Metabolic Information to the Brain: Short-Term and Long-Term Regulation of Food Intake and Energy Homeostasis
Experimental Biology and Medicine, December 1, 2001; 226(11): 963 - 977.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online