AJP - Endocrinology and Metabolism, Vol 254, Issue 4 E389-E393, Copyright © 1988 by American Physiological Society
Renin substrate release in response to perturbations of renin-angiotensin system
P. Eggena and J. D. Barrett
Renin Biochemistry Laboratory, Veterans Administration Medical Center, Sepulveda, California 91343.
The role of the kidney in the regulation of plasma renin substrate and the
release of this protein from rat liver slices were investigated.
Physiological and pharmacological maneuvers were performed to perturb the
renin-angiotensin system, including 24-h bilateral nephrectomy and
furosemide administration to change renin and adrenalectomy and
administration of dexamethasone to alter renin substrate. In the normal
physiological range of plasma renin activity (PRA), no statistically
significant linear relationship was evident between PRA and either plasma
renin substrate or renin substrate released from liver slices. Stimulation
of renin substrate by nephrectomy and dexamethasone administration were
additive. Nephrectomy was also shown not to induce the release of a renin
substrate-stimulating factor.
