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Am J Physiol Endocrinol Metab 254: E323-E327, 1988;
0193-1849/88 $5.00
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AJP - Endocrinology and Metabolism, Vol 254, Issue 3 E323-E327, Copyright © 1988 by American Physiological Society

ARTICLES

Phorbol esters, protein kinase C, and thyroxine 5'-deiodinase in brown adipocytes

R. M. Barge, I. Mills, J. E. Silva and P. R. Larsen
Howard Hughes Medical Institute Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115.

Protein kinase C activity has been identified in the rat brown adipocyte. About 60% of this activity is found in the cytosolic fraction under basal conditions, and 12-O-tetradecanoylphorbol 13-acetate (TPA) causes a rapid shift from the cytosol to the particulate fraction. Norepinephrine and phenylephrine cause a similar redistribution that can be blocked by prazosin but not by alprenolol. alpha 1-Adrenergic agonists cause three- to fivefold stimulation of type 2 iodothyronine 5'-deiodinase activity in brown adipocytes. TPA has no effect on basal deiodinase activity and reduces the response of the enzyme to alpha 1-adrenergic agonists. These results suggest that the translocation of protein kinase C from cytosol to particulate fraction is not sufficient to increase deiodinase activity but can modulate the alpha 1-adrenergic agonist-mediated responses in these cells.


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