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Am J Physiol Endocrinol Metab 254: E231-E236, 1988;
0193-1849/88 $5.00
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AJP - Endocrinology and Metabolism, Vol 254, Issue 2 E231-E236, Copyright © 1988 by American Physiological Society

ARTICLES

Insulin response of components of whole-body and muscle carbohydrate metabolism in humans

A. A. Young, C. Bogardus, K. Stone and D. M. Mott
Clinical Diabetes and Nutrition Section, National Institute of Arthritis and Digestive and Kidney Diseases, Phoenix, Arizona 85016.

We measured total body insulin-mediated glucose uptake, carbohydrate oxidation, storage (nonoxidative disposal), muscle glycogen synthase activity, and muscle glucose 6-phosphate (G-6-P) content in response to five levels of insulinemia (means 16, 52, 152, 573, and 5,550 microU/ml) in 16 male glucose-tolerant volunteers. Insulin dissociation constants (KDs) for disposal, storage, and synthase activity (but not for oxidation) are coincident, suggesting that storage via glycogen synthesis could be a major determinant of glucose disposal. Increases in glucose disposal were associated with decreases in muscle G-6-P concentration. These data suggest that the principal control over carbohydrate disposal is exerted after G-6-P. The coincidence of insulin sensitivities for disposal, storage, and synthase activity suggest that storage via glycogen synthesis could be a major determinant of glucose disposal.


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