AJP - Endo AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 253: E565-E574, 1987;
0193-1849/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McIntosh, T. K.
Right arrow Articles by Faden, A. I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McIntosh, T. K.
Right arrow Articles by Faden, A. I.

AJP - Endocrinology and Metabolism, Vol 253, Issue 5 E565-E574, Copyright © 1987 by American Physiological Society

ARTICLES

Endogenous opioids may mediate secondary damage after experimental brain injury

T. K. McIntosh, R. L. Hayes, D. S. DeWitt, V. Agura and A. I. Faden
Department of Neurology, University of California, San Francisco.

Although endogenous opioids have been implicated in the pathophysiology of spinal cord injury and brain ischemia, the role of specific opioid peptides and opiate receptors in the pathophysiology of traumatic brain injury remains unexplored. This study examined regional changes in brain opioid immunoreactivity and cerebral blood flow (CBF) after fluid-percussion brain injury in the cat and compared the effect of an opiate antagonist (Win 44,441-3 [Win-(-)]) with its dextroisomer Win 44,441-2 [Win-(+)] (which is inactive at opiate receptors) in the treatment of brain injury. Dynorphin A immunoreactivity (Dyn A-IR) but not leucine-enkephalin-like immunoreactivity accumulated in injury regions after traumatic injury; Dyn-IR increases also occurred predominantly in those areas showing significant decreases in regional CBF. Administration of Win-(-) but not Win-(+) or saline at 15 min after injury significantly improved mean arterial pressure, electroencephalographic amplitude, and regional CBF and reduced the severity and incidence of hemorrhage. Win-(-) also significantly improved survival after brain injury. Taken together, these findings suggest that dynorphin, through actions at opiate receptors, may contribute to the pathophysiology of secondary brain injury after head trauma and indicate that selective opiate-receptor antagonists may be useful in treatment of traumatic brain injury.


This article has been cited by other articles:


Home page
 StrokeHome page
W. M. Armstead
Vasopressin-Induced Protein Kinase C-Dependent Superoxide Generation Contributes to ATP-Sensitive Potassium Channel but Not Calcium-Sensitive Potassium Channel Function Impairment After Brain Injury
Stroke, June 1, 2001; 32(6): 1408 - 1414.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. M. Armstead
NOC/oFQ contributes to age-dependent impairment of NMDA-induced cerebrovasodilation after brain injury
Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2188 - H2195.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. M. Armstead
Role of endothelin-1 in age-dependent cerebrovascular hypotensive responses after brain injury
Am J Physiol Heart Circ Physiol, November 1, 1999; 277(5): H1884 - H1894.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
T. Kasemsri, W. M. Armstead, and L. J. Noble
Endothelin Production Links Superoxide Generation to Altered Opioid-Induced Pial Artery Vasodilation After Brain Injury in Pigs
Stroke, January 1, 1997; 28(1): 190 - 197.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online