AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 253: E461-E466, 1987;
0193-1849/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brooks, G. A.
Right arrow Articles by Dallman, P. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brooks, G. A.
Right arrow Articles by Dallman, P. R.

AJP - Endocrinology and Metabolism, Vol 253, Issue 4 E461-E466, Copyright © 1987 by American Physiological Society

ARTICLES

Increased glucose dependence in resting, iron-deficient rats

G. A. Brooks, S. A. Henderson and P. R. Dallman
Department of Physical Education, University of California, Berkeley 94720.

Rates of blood glucose and lactate turnover were assessed in resting iron-deficient and iron-sufficient (control) rats to test the hypothesis that dependence on glucose metabolism is increased in iron deficiency. Male Sprague-Dawley rats, 21 days old, were fed a diet containing either 6 mg iron/kg feed (iron-deficient group) or 50 mg iron/kg feed (iron-sufficient group) for 3-4 wk. The iron-deficient group became anemic, with hemoglobin levels of 6.4 +/- 0.2 compared with 13.8 +/- 0.3 g/dl for controls. Rats received a 90-min primed continuous infusion of D-[6-3H]glucose and sodium L-[U-14C]lactate via a jugular catheter. Serial samples were taken from a carotid catheter for concentration and specific activity determinations. Iron-deficient rats had significantly (P less than 0.05) higher blood glucose (7.1 +/- 0.3 vs. 6.1 +/- 0.2 mM) and lactate concentrations than controls (1.0 +/- 0.1 vs. 0.8 +/- 0.1 mM). The iron-deficient group had a significantly higher glucose turnover rate (67 +/- 2 vs. 58 +/- 4 mumol . kg-1 . min-1) than the control group. Significantly more metabolite recycling in iron-deficient rats was indicated by greater incorporation of 14C (from infused [14C]-lactate) into blood glucose. Assuming a carbon crossover correction factor of 2, half of blood glucose arose from lactate in deficient animals. By comparison, only 25% of glucose arose from lactate in controls. Lack of a difference in lactate turnover (irreversible disposal) rates between deficient rats and controls (191 +/- 26 vs. 163 +/- 15 mumol . kg-1 . min-1) was attributed to 14C recycling.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
T. D Brutsaert, S. Hernandez-Cordero, J. Rivera, T. Viola, G. Hughes, and J. D Haas
Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women
Am. J. Clinical Nutrition, February 1, 2003; 77(2): 441 - 448.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
K. L. Ross and R. S. Eisenstein
Iron Deficiency Decreases Mitochondrial Aconitase Abundance and Citrate Concentration without Affecting Tricarboxylic Acid Cycle Capacity in Rat Liver
J. Nutr., April 1, 2002; 132(4): 643 - 651.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. J. Borel, M. S. Buchowski, E. A. Turner, B. B. Peeler, R. E. Goldstein, and P. J. Flakoll
Alterations in basal nutrient metabolism increase resting energy expenditure in sickle cell disease
Am J Physiol Endocrinol Metab, February 1, 1998; 274(2): E357 - E364.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online