AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 253: E214-E220, 1987;
0193-1849/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Leijendekker, W. J.
Right arrow Articles by Elzinga, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Leijendekker, W. J.
Right arrow Articles by Elzinga, G.

AJP - Endocrinology and Metabolism, Vol 253, Issue 2 E214-E220, Copyright © 1987 by American Physiological Society

ARTICLES

Heat production during contraction in skeletal muscle of hypothyroid mice

W. J. Leijendekker, C. van Hardeveld and G. Elzinga

The effect of hypothyroidism on tension-independent and -dependent heat produced during a twitch and a tetanic contraction of extensor digitorum longus (EDL) and soleus muscle of mice was examined. The amount of heat produced during a twitch and the rate of heat development during a tetanus of EDL and soleus were measured at and above optimal length. The effect of hypothyroidism on force production was less than 30%. Straight lines were used to fit the relation between heat production and force. Hypothyroidism significantly decreases tension-independent heat during contraction of EDL and soleus muscle. Because the tension-independent heat is considered to be related to the Ca2+ cycling, these findings suggest that ATP splitting due to the Ca2+ cycling is reduced in hypothyroid mice. This conclusion was strengthened by the observation that the oxalate-supported Ca2+-uptake activity and Ca2+-loading capacity of muscle homogenates from hypothyroid mice were reduced, respectively, to 51 and to 65% in soleus and to 63 and 73% in EDL muscle as compared with euthyroid mice. The tension-dependent rate of heat development during a tetanus was also decreased in soleus muscle of hypothyroid mice. This suggests a lower rate of ATP hydrolysis related to cross-bridge cycling in this muscle due to the hypothyroid state.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Fredsted, H. Gissel, K. Madsen, and T. Clausen
Causes of excitation-induced muscle cell damage in isometric contractions: mechanical stress or calcium overload?
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2249 - R2258.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. E. Silva
Thermogenic Mechanisms and Their Hormonal Regulation
Physiol Rev, April 1, 2006; 86(2): 435 - 464.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
J. E. Silva
The Thermogenic Effect of Thyroid Hormone and Its Clinical Implications
Ann Intern Med, August 5, 2003; 139(3): 205 - 213.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. A. Levine, J. Nygren, K. R. Short, and K. S. Nair
Effect of hyperthyroidism on spontaneous physical activity and energy expenditure in rats
J Appl Physiol, January 1, 2003; 94(1): 165 - 170.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online