AJP - Endocrinology and Metabolism, Vol 253, Issue 2 E158-E164, Copyright © 1987 by American Physiological Society
Comparison of glucose and glucose plus lipid as caloric sources in parenterally fed rats
S. Lanza-Jacoby, A. Tabares, H. S. Sitren and E. Kosar
This study investigated the etiology of fat infiltration of the liver
during total parenteral nutrition. We measured the content of liver lipids,
serum lipids, liver lipogenic enzymes, rates of in vivo fatty acid
synthesis, and carcass composition in rats during continuous intravenous
(iv) and intragastric (ig) feeding of two diets containing either 100%
glucose or 75% glucose-25% lipid (20% Intralipid). Two groups of orally (O)
fed rats were given solid diets similar to either the glucose or
glucose-lipid solution in energy and nitrogen content. All six groups of
rats (285-295 g) received 230 kcal X kg-1 X day -1 and 766 mg N X kg-1 X
day-1. Total liver fat was greater after feeding the glucose diet ig rather
than iv. However, feeding the glucose-lipid diet ig but not iv reduced the
accumulation of liver fat by 49%. There were no differences in serum
glucose concentrations among the three groups fed the glucose solution.
Serum glucose concentrations in iv and O rats fed either diet were not
significantly different; whereas feeding the glucose-lipid solution ig
lowered serum glucose compared with the 100% glucose solution. Insulin
concentrations were similar among all groups. The concentrations of serum
triglycerides and cholesterol were higher in the groups fed the
glucose-lipid diet. The activities of the liver lipogenic enzymes and rates
of fatty acid synthesis were higher in iv- and ig-fed rats receiving the
glucose diet compared with the glucose-lipid diet.(ABSTRACT TRUNCATED AT
250 WORDS)
