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Am J Physiol Endocrinol Metab 252: E370-E374, 1987;
0193-1849/87 $5.00
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AJP - Endocrinology and Metabolism, Vol 252, Issue 3 E370-E374, Copyright © 1987 by American Physiological Society

ARTICLES

Asperlicin antagonizes stimulatory effects of cholecystokinin on isolated islets

W. S. Zawalich and V. A. Diaz

Asperlicin, a product derived from the fungus Aspergillus alliaceus, antagonized the multiple stimulatory effects of cholecystokinin (CCK-8S) on isolated islets. At a level of 10 microM, asperlicin completely inhibited insulin release in response to 25 nM CCK-8S. Increasing the level of CCK-8S to 100 nM partially restored a secretory response, while an even greater insulin stimulatory effect was noted with 500 nM CCK-8S. The inhibitory effect of asperlicin on CCK-8S-induced release was reversible. Asperlicin exposure had no effect on glucose or glyceraldehyde-induced secretion. Asperlicin reduced, in parallel with secretion, the increase in 3H efflux from [3H]inositol prelabeled islets usually noted with CCK-8S addition. Asperlicin did not influence the small glucose-stimulated increase in 3H efflux. The results support the notion that asperlicin is a specific and potent antagonist of the multiple stimulatory effects of CCK-8S on islet tissue.




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