AJP - Endocrinology and Metabolism, Vol 252, Issue 2 E218-E223, Copyright © 1987 by American Physiological Society

ARTICLES

Lipolytic response to glucose infusion in human subjects

R. R. Wolfe and E. J. Peters

We have determined the effect of various rates of glucose infusion on the rates of release of glycerol (Ra glycerol), free fatty acids (Ra FFA), and on energy metabolism in normal human volunteers. Plasma kinetics were determined with use of the stable isotopic tracers D-5-glycerol and [1-13C]palmitate, and energy metabolism was determined by indirect calorimetry. The effect of glucose infusion on Ra glycerol and Ra FFA was dose-dependent. At an infusion rate of 1 mg X kg-1 X min-1, no effect on either kinetic factor was noted. At 4 mg X kg-1 X min-1, both Ra glycerol and Ra FFA were suppressed; at 8 mg X kg-1 X min-1, Ra FFA was even more depressed, but Ra glycerol was similar to the value during the 4 mg X kg-1 X min-1 infusion. At all infusion rates tested, the amount of potential energy available from the sum of the glucose infusion and endogenously mobilized fat was always greater than when no glucose was infused. Glucose decreased fat mobilization by both inhibiting lipolysis and stimulating reesterification, thus causing a significant increase in triglyceride-fatty acid substrate cycling within the adipose tissue.

This article has been cited by other articles:

				S. F. Bernard, J. Orvoine, and R. Groscolas Glucose regulates lipid metabolism in fasting king penguins Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R313 - R320. [Abstract] [Full Text] [PDF]

				K. Evans, G. C. Burdge, S. A. Wootton, M. L. Clark, and K. N. Frayn Regulation of Dietary Fatty Acid Entrapment in Subcutaneous Adipose Tissue and Skeletal Muscle Diabetes, September 1, 2002; 51(9): 2684 - 2690. [Abstract] [Full Text] [PDF]

				S. R. Commerford, M. J. Pagliassotti, C. L. Melby, Y. Wei, E. C. Gayles, and J. O. Hill Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E875 - E885. [Abstract] [Full Text] [PDF]

				S. W. Coppack, M. Persson, R. L. Judd, and J. M. Miles Glycerol and nonesterified fatty acid metabolism in human muscle and adipose tissue in vivo Am J Physiol Endocrinol Metab, February 1, 1999; 276(2): E233 - E240. [Abstract] [Full Text] [PDF]

				K. Evans, M. L. Clark, and K. N. Frayn Effects of an oral and intravenous fat load on adipose tissue and forearm lipid metabolism Am J Physiol Endocrinol Metab, February 1, 1999; 276(2): E241 - E248. [Abstract] [Full Text] [PDF]

				F. Haman, G. Zwingelstein, and J.-M. Weber Effects of hypoxia and low temperature on substrate fluxes in fish: plasma metabolite concentrations are misleading Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1997; 273(6): R2046 - R2054. [Abstract] [Full Text] [PDF]

				A. Laws, H.M. Hoen, J.V. Selby, M.F. Saad, S.M. Haffner, and B.V. Howard Differences in Insulin Suppression of Free Fatty Acid Levels by Gender and Glucose Tolerance Status: Relation to Plasma Triglyceride and Apolipoprotein B Concentrations Arterioscler. Thromb. Vasc. Biol., January 1, 1997; 17(1): 64 - 71. [Abstract] [Full Text]