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Am J Physiol Endocrinol Metab 251: E639-E643, 1986;
0193-1849/86 $5.00
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AJP - Endocrinology and Metabolism, Vol 251, Issue 6 639-E643, Copyright © 1986 by American Physiological Society

ARTICLES

Hormonal regulation of iodothyronine 5'-deiodinase in rat brown adipose tissue

J. E. Silva and P. R. Larsen

Norepinephrine, isoproterenol, insulin, and glucagon increase the type II (low Km) iodothyronine 5'-deiodinase (5'-D) in the brown adipose tissue (BAT) of intact rats. Cycloheximide or actinomycin D blocks the increase after norepinephrine, suggesting new mRNA synthesis is required for this effect. The 3- to 10-fold increase in BAT 5'-D after insulin administration was also blocked by cycloheximide. The effects of all stimulators are blunted by fasting or streptozotocin-induced diabetes. While all these hormones have the potential for stimulating BAT 5'-D, the dose-response relationships suggest that norepinephrine and insulin are the most potent. These and our earlier studies showing additional effects of thyroid and growth hormones on BAT 5'-D point to the complex regulation of this enzyme, suggesting that the triiodothyronine produced from its action has an important role in the thermogenic response of this tissue.


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