AJP - Endocrinology and Metabolism, Vol 251, Issue 3 299-E305, Copyright © 1986 by American Physiological Society

ARTICLES

Exercise and diet reduce muscle insulin resistance in obese Zucker rat

J. L. Ivy, W. M. Sherman, C. L. Cutler and A. L. Katz

Two treatments that increase skeletal muscle insulin action are exercise training and high-carbohydrate diet. The purpose of the present study was to determine whether exercise training and a diet high in carbohydrates could function synergistically to reduce the muscle insulin resistance in the obese Zucker rat. Obese rats 4 wk of age were randomly assigned to an exercise or sedentary group. Each group was subdivided by diet with one-half of the rats fed a high-carbohydrate diet and one-half fed a high-fat diet. Lean Zucker rats fed the high-fat diet were used as controls. Muscle insulin resistance was assessed during hindlimb perfusion with a submaximally stimulating concentration of insulin. Exercise training and the high-carbohydrate diet increased the rate of muscle glucose uptake in the obese rat by 46 and 53%, respectively. More importantly, the combined effect of exercise training and high-carbohydrate diet was greater than the sum of their individual effects. Glycogen synthesis paralleled glucose uptake and was the major pathway for intracellular glucose disposal. Muscle glucose uptake for exercise-trained, high-carbohydrate fed obese rats was comparable with that of lean controls. It is concluded that exercise training and the high-carbohydrate diet functioned synergistically to reduce the muscle insulin resistance in the obese rat.

This article has been cited by other articles:

				A. C. Smith, K. L. Mullen, K. A. Junkin, J. Nickerson, A. Chabowski, A. Bonen, and D. J. Dyck Metformin and exercise reduce muscle FAT/CD36 and lipid accumulation and blunt the progression of high-fat diet-induced hyperglycemia Am J Physiol Endocrinol Metab, July 1, 2007; 293(1): E172 - E181. [Abstract] [Full Text] [PDF]

				E. J. Henriksen Exercise Effects of Muscle Insulin Signaling and Action: Invited Review: Effects of acute exercise and exercise training on insulin resistance J Appl Physiol, August 1, 2002; 93(2): 788 - 796. [Abstract] [Full Text] [PDF]

				C. Y. Christ, D. Hunt, J. Hancock, R. Garcia-Macedo, L. J. Mandarino, and J. L. Ivy Exercise training improves muscle insulin resistance but not insulin receptor signaling in obese Zucker rats J Appl Physiol, February 1, 2002; 92(2): 736 - 744. [Abstract] [Full Text] [PDF]

				C. R. Bruce, J. S. Lee, and J. A. Hawley Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats J Appl Physiol, October 1, 2001; 91(4): 1512 - 1519. [Abstract] [Full Text] [PDF]

				V. Saengsirisuwan, T. R. Kinnick, M. B. Schmit, and E. J. Henriksen Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats J Appl Physiol, July 1, 2001; 91(1): 145 - 153. [Abstract] [Full Text] [PDF]

				L. P. Turcotte, J. R. Swenberger, M. Zavitz Tucker, and A. J. Yee Increased Fatty Acid Uptake and Altered Fatty Acid Metabolism in Insulin-Resistant Muscle of Obese Zucker Rats Diabetes, June 1, 2001; 50(6): 1389 - 1396. [Abstract] [Full Text]

				K. J. Ayre, S. D. Phinney, A. B. Tang, and J. S. Stern Exercise training reduces skeletal muscle membrane arachidonate in the obese (fa/fa) Zucker rat J Appl Physiol, November 1, 1998; 85(5): 1898 - 1902. [Abstract] [Full Text] [PDF]

				A. L. Castle, C.-H. Kuo, D.-H. Han, and J. L. Ivy Amylin-mediated inhibition of insulin-stimulated glucose transport in skeletal muscle Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E531 - E536. [Abstract] [Full Text] [PDF]

				A. L. Castle, C.-H. Kuo, and J. L. Ivy Amylin influences insulin-stimulated glucose metabolism by two independent mechanisms Am J Physiol Endocrinol Metab, January 1, 1998; 274(1): E6 - E12. [Abstract] [Full Text] [PDF]

				P. H. McNulty, R. J. Louard, L. I. Deckelbaum, B. L. Zaret, and L. H. Young Hyperinsulinemia Inhibits Myocardial Protein Degradation in Patients With Cardiovascular Disease and Insulin Resistance Circulation, October 15, 1995; 92(8): 2151 - 2156. [Abstract] [Full Text]