AJP - Endo Cosmo Bio: Excellent Endocrine ELISAs
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 250: E495-E501, 1986;
0193-1849/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fery, F.
Right arrow Articles by Balasse, E. O.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fery, F.
Right arrow Articles by Balasse, E. O.

AJP - Endocrinology and Metabolism, Vol 250, Issue 5 495-E501, Copyright © 1986 by American Physiological Society

ARTICLES

Response of ketone body metabolism to exercise during transition from postabsorptive to fasted state

F. Fery and E. O. Balasse

This study examines the effects of a 2-h exercise of moderate intensity (50% of VO2 max) on the tracer-determined turnover rate of ketone bodies (KB) in 21 normal subjects fasted for 16 h, 5 days, whose basal ketonemia ranged between 0.09 and 6.16 mM. The KB response observed at the end of exercise is a function of the initial degree of ketosis. When basal ketonemia is below 0.6 mM, exercise enhances ketogenesis (Ra), the amplitude of this process being positively correlated with KB level. There is a concomitant acceleration of the metabolic clearance rate (MCR) of KB attaining 40-50%. When ketonemia exceeds 2.5 mM, the stimulatory effects of exercise on Ra and on MCR become less marked as basal ketonemia rises and are completely abolished or even reversed when initial KB level is higher than 3-4 mM. The pattern of changes in the concentration and in the overall disposal rate of KB were similar to that of Ra. It is suggested that the parallel inhibition of the stimulatory effect of work on hepatic ketogenesis and on muscular extraction of ketones associated with increasing degrees of fasting hyperketonemia has two physiological implications: it maintains the preferential utilization of KB by nonmuscular tissues (presumably the brain) and prevents the development of uncontrolled hyperketonemia, despite the intense catabolic situation created by the combination of exercise and starvation.


This article has been cited by other articles:


Home page
 J. Exp. Biol.Home page
S. Jenni-Eiermann, L. Jenni, A. Kvist, A. Lindstrom, T. Piersma, and G. H. Visser
Fuel use and metabolic response to endurance exercise: a wind tunnel study of a long-distance migrant shorebird
J. Exp. Biol., August 15, 2002; 205(16): 2453 - 2460.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. Namdaran, D. P. Bracy, D. B. Lacy, J. L. Johnson, J. L. Bupp, and D. H. Wasserman
Gut and liver fat metabolism in depancreatized dogs: effects of exercise and acute insulin infusion
J Appl Physiol, October 1, 1997; 83(4): 1339 - 1347.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online