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AJP - Endocrinology and Metabolism, Vol 250, Issue 4 486-E493, Copyright © 1986 by American Physiological Society
ARTICLES |
J. D. Veldhuis and M. L. Johnson
Endocrine signaling provides one critical means of physiological communication within an organism. Many endocrine signals exhibit an episodic or pulsatile configuration. In an effort to provide a versatile and statistically based algorithm for investigating the regulation of endocrine pulse signals, we have formulated a computerized algorithm in which a pulse is defined as a statistically significant increase in a "cluster" of hormone values followed by a statistically significant decrease in a second cluster of values. The increase or decrease is judged in relation to the actual experimental error expressed by the replicates in the presumptive nadir and peak data clusters. The program permits the operator to specify the cluster sizes of test peaks and pre- and postpeak nadirs. This method is largely insensitive to unstable base-line hormone concentrations and is not adversely affected by varying pulse amplitudes, widths, or configurations within the endocrine series. In addition, the simple statistical basis for this algorithm renders it minimally dependent on explicit or a priori assumptions about rates of hormone secretion or disappearance. The program has been validated for false-positive errors against a wide range of intraseries coefficients of variation (4-52%). We have illustrated its performance for profiles of luteinizing hormone, follicle-stimulating hormone, growth hormone, prolactin, adrenocorticotropic hormone, and cortisol and compared these episodic patterns with those of stable serum constituents (total serum protein and calcium), which do not exhibit pulsatile fluctuation.
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J.-C. Painson, J. D. Veldhuis, and G. S. Tannenbaum Single exposure to testosterone in adulthood rapidly induces regularity in the growth hormone release process Am J Physiol Endocrinol Metab, May 1, 2000; 278(5): E933 - E940. [Abstract] [Full Text] [PDF]
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N. Porksen, C. Juhl, M. Hollingdal, S. M. Pincus, J. Sturis, J. D. Veldhuis, and O. Schmitz Concordant induction of rapid in vivo pulsatile insulin secretion by recurrent punctuated glucose infusions Am J Physiol Endocrinol Metab, January 1, 2000; 278(1): E162 - E170. [Abstract] [Full Text] [PDF]
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L. Wideman, J. Y. Weltman, N. Shah, S. Story, J. D. Veldhuis, and A. Weltman Effects of gender on exercise-induced growth hormone release J Appl Physiol, September 1, 1999; 87(3): 1154 - 1162. [Abstract] [Full Text] [PDF]
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C. J. Pritzlaff, L. Wideman, J. Y. Weltman, R. D. Abbott, M. E. Gutgesell, M. L. Hartman, J. D. Veldhuis, and A. Weltman Impact of acute exercise intensity on pulsatile growth hormone release in men J Appl Physiol, August 1, 1999; 87(2): 498 - 504. [Abstract] [Full Text] [PDF]
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T. Sir-Petermann, V. Piwonka, F. Perez, M. Maliqueo, S.E. Recabarren, and L. Wildt Are circulating leptin and luteinizing hormone synchronized in patients with polycystic ovary syndrome? Hum. Reprod., June 1, 1999; 14(6): 1435 - 1439. [Abstract] [Full Text] [PDF]
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N. Shah, W. S. Evans, and J. D. Veldhuis Actions of estrogen on pulsatile, nyctohemeral, and entropic modes of growth hormone secretion Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1351 - R1358. [Abstract] [Full Text] [PDF]
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 D. Fliser, J. D. Veldhuis, R. Dikow, H. Schmidt-Gayk, and E. Ritz Effects of Acute ACE Inhibition on Pulsatile Renin and Aldosterone Secretion and Their Synchrony Hypertension, November 1, 1998; 32(5): 929 - 934. [Abstract] [Full Text] [PDF]
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F. B. Diamond, E. V. Jorgensen, A. W. Root, D. I. Shulman, J. P. Sy, S. L. Blethen, and B. B. Bercu The Role of Serial Sampling in the Diagnosis of Growth Hormone Deficiency Pediatrics, August 1, 1998; 102(2): 521 - 524. [Abstract] [Full Text]
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 J. Licinio, A. B. Negrao, C. Mantzoros, V. Kaklamani, M.-L. Wong, P. B. Bongiorno, A. Mulla, L. Cearnal, J. D. Veldhuis, J. S. Flier, et al. Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women PNAS, March 3, 1998; 95(5): 2541 - 2546. [Abstract] [Full Text] [PDF]
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J. A. Kanaley, J. Y. Weltman, J. D. Veldhuis, A. D. Rogol, M. L. Hartman, and A. Weltman Human growth hormone response to repeated bouts of aerobic exercise J Appl Physiol, November 1, 1997; 83(5): 1756 - 1761. [Abstract] [Full Text] [PDF]
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H. J. Lee, G. Riley, O. Johnson, J. L. Cleland, N. Kim, M. Charnis, L. Bailey, E. Duenas, A. Shahzamani, M. Marian, et al. J. Pharmacol. Exp. Ther., June 1, 1997; 281(3): 1431 - 1439. [Abstract]
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G. F. DiBona and S. Y. Jones Analysis of Renal Sympathetic Nerve Responses to Stress Hypertension, April 1, 1995; 25(4): 531 - 538. [Abstract] [Full Text]
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C. J. Pritzlaff-Roy, L. Widemen, J. Y. Weltman, R. Abbott, M. Gutgesell, M. L. Hartman, J. D. Veldhuis, and A. Weltman Gender governs the relationship between exercise intensity and growth hormone release in young adults J Appl Physiol, May 1, 2002; 92(5): 2053 - 2060. [Abstract] [Full Text] [PDF]
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E. A. Vitalis, J. L. Costantin, P.-S. Tsai, H. Sakakibara, S. Paruthiyil, T. Iiri, J.-F. Martini, M. Taga, A. L. H. Choi, A. C. Charles, et al. Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing hormone secretion in GT1 cells PNAS, February 15, 2000; 97(4): 1861 - 1866. [Abstract] [Full Text] [PDF]
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E. W. C. M. Van Dam, F. Roelfsema, J. D. Veldhuis, F. M. Helmerhorst, M. Frolich, A. E. Meinders, H. M. J. Krans, and H. Pijl Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E865 - E872. [Abstract] [Full Text] [PDF]
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H. G. Maheshwari, S. S. Pezzoli, A. Rahim, S. M. Shalet, M. O. Thorner, and G. Baumann Pulsatile growth hormone secretion persists in genetic growth hormone-releasing hormone resistance Am J Physiol Endocrinol Metab, April 1, 2002; 282(4): E943 - E951. [Abstract] [Full Text] [PDF]
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