AJP - Endo Journal of Applied Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 250: E386-E392, 1986;
0193-1849/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lakshmanan, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lakshmanan, J.

AJP - Endocrinology and Metabolism, Vol 250, Issue 4 386-E392, Copyright © 1986 by American Physiological Society

ARTICLES

Aggressive behavior in adult male mice elevates serum nerve growth factor levels

J. Lakshmanan

By use of a specific and sensitive beta-nerve growth factor radioimmunoassay (beta NGF-RIA), serum beta NGF concentrations were measured in adult male Swiss-Webster mice under various physiological conditions. Animals killed on the day of arrival from the animal supplier showed wide variations (3-15 ng beta NGF/ml) in serum beta NGF levels. These levels significantly decreased if the animals were maintained under individually housed conditions for at least 6 days prior to death. Aggression caused by social contact between previously individually housed animals raised serum beta NGF levels by two orders of magnitude relative to serum beta NGF concentrations in nonaggressive mice. Testosterone propionate treatment (10 mg/animal) 5 days prior to death did not elevate serum beta NGF levels in individually maintained animals. However, the hormone pretreatment markedly augmented serum beta NGF levels in aggressive mice compared with the levels in hormone-treated nonaggressive animals. Removal of the submandibular-sublingual salivary glands 10 days prior to death completely abolished the increase in serum beta NGF due to aggression. The high serum beta NGF levels, as measured by competitive RIA in aggressive mice, were confirmed by a neurite outgrowth PC-12 bioassay system. In conclusion, serum beta NGF in adult male mice is subject to alteration by environmental stress.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
O. Sanchez, M. Viladrich, I. Ramirez, and M. Soley
Liver injury after an aggressive encounter in male mice
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2007; 293(5): R1908 - R1916.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online