AJP - Endocrinology and Metabolism, Vol 250, Issue 3 312-E318, Copyright © 1986 by American Physiological Society
Comparison of glucose, LCT, and LCT plus MCT as calorie sources for parenterally nourished septic rats
T. P. Stein, R. C. Fried, M. H. Torosian, M. J. Leskiw, M. D. Schluter, R. G. Settle and G. P. Buzby
Protein and energy metabolism were investigated in acutely septic rats.
Rats were made septic by cecal puncture and ligation. For the next 24 h
they were given one of five parenteral formulations differing only in the
nonprotein calorie source. The five calorie sources were 1) glucose, 2)
long-chain triglycerides (LCT), 3) a 27:73 mixture of medium- and
long-chain triglycerides (M/LCT), 4) a 50:50 mixture of glucose plus LCT,
and 5) a 50:50 mixture of glucose plus the M/LCT mixture. The formulations
also contained amino acids at a calorie:ratio of 165:1. The results were
that N retention was greater with the glucose plus LCT mixture than with
glucose alone. With this mixture, N retention increased as calorie intake
increased, whereas with glucose, N retention plateaued. In spite of the
high glucose load given to the glucose-only groups, there was a significant
reduction in endogenous fat in peripheral depots. Lipid loss was least with
the glucose plus LCT combination. The M/LCT mixture given alone or with
glucose resulted in significantly lower survival rates.
