AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 250: E205-E211, 1986;
0193-1849/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bergen, H.
Right arrow Articles by Leung, P. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bergen, H.
Right arrow Articles by Leung, P. C.

AJP - Endocrinology and Metabolism, Vol 250, Issue 2 205-E211, Copyright © 1986 by American Physiological Society

ARTICLES

Norepinephrine inhibition of pulsatile LH release: receptor specificity

H. Bergen and P. C. Leung

Infusion of norepinephrine (NE) into the third ventricle of ovariectomized (OVX) adult rats inhibits pulsatile luteinizing hormone (LH) secretion. This study examines the effects of pretreatment with specific alpha- and beta-adrenergic blockers on the subsequent NE-induced suppression of LH release. Unanesthetized long-term OVX rats were injected ip or iv with phenoxybenzamine (alpha-adrenergic receptor blocker), propranolol (beta-adrenergic blocker), or an equal volume of saline (as controls). Approximately 1-1.5 h later, the animals were given an intraventricular (ivt) administration of NE. Infusion of acidified saline into the third ventricle of OVX rats failed to affect the pulsatile pattern of LH release characteristic of these animals. After ivt of NE, the control rats showed a significant decrease in mean blood LH level of ca. 30%. Pretreatment of OVX rat with propranolol either ivt or ip failed to affect pulsatile LH release. Subsequent ivt infusion of NE either at 1 h or 15 min after propranolol treatment also caused a 28-30% decrease in the mean LH levels and suppressed pulsatile discharge of LH, an effect that lasted for approximately 45-50 min. In sharp contrast to the saline and propranolol-treated groups, rats pretreated with phenoxybenzamine had sporadic or no LH pulses during the 70-min postphenoxybenzamine period and had significantly lower mean LH levels when compared with control animals (P less than 0.05). Moreover, a drop in mean blood LH levels after NE infusion was not observed in the rats pretreated with phenoxybenzamine.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
C. De Cree, P. Ball, B. Seidlitz, G. Van Kranenburg, P. Geurten, and H. A. Keizer
Effects of a training program on resting plasma 2-hydroxycatecholestrogen levels in eumenorrheic women
J Appl Physiol, November 1, 1997; 83(5): 1551 - 1556.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online