AJP - Endo AJP: Cell Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 250: E169-E178, 1986;
0193-1849/86 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hawkins, R. A.
Right arrow Articles by Davis, D. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hawkins, R. A.
Right arrow Articles by Davis, D. W.

AJP - Endocrinology and Metabolism, Vol 250, Issue 2 169-E178, Copyright © 1986 by American Physiological Society

ARTICLES

Regional ketone body utilization by rat brain in starvation and diabetes

R. A. Hawkins, A. M. Mans and D. W. Davis

The rate of ketone body (beta-hydroxybutyrate and acetoacetate) metabolism was measured in individual cerebral structures of fed, starved, and diabetic rats. This was done by infusing beta-[3-14C]hydroxybutyrate intravenously and measuring the incorporation of 14C into brain by quantitative autoradiography. The capacity of the brain to use ketone bodies, expressed as plasma clearance, increased in starvation and diabetes by approximately 50-60%. Plasma clearance was near maximal after 2 days starvation and was not significantly increased after 4 days starvation, 6 days of diabetes or 28 days of diabetes. In all situations the ketone bodies provided only a modest amount of fuel for brain energy metabolism; 3.2% after 2 days starvation and 6.5 and 9.9% after 6 and 28 days of diabetes. The fraction of their energy requirement which the various structures could derive from the ketone bodies differed widely. In general the telencephalon made greatest use of ketone bodies, whereas the hindbrain used least. There was no correlation between the energy requirement of structures (estimated from glucose use in fed rats) and the fraction of energy they could derive from ketone bodies.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
K. Pierre, A. Parent, P.-Y. Jayet, A. P. Halestrap, U. Scherrer, and L. Pellerin
Enhanced expression of three monocarboxylate transporter isoforms in the brain of obese mice
J. Physiol., September 1, 2007; 583(2): 469 - 486.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. J. Vannucci and I. A. Simpson
Developmental switch in brain nutrient transporter expression in the rat
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1127 - E1134.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. M. Koehler-Stec, I. A. Simpson, S. J. Vannucci, K. T. Landschulz, and W. H. Landschulz
Monocarboxylate transporter expression in mouse brain
Am J Physiol Endocrinol Metab, September 1, 1998; 275(3): E516 - E524.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online