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Am J Physiol Endocrinol Metab 248: E463-E470, 1985;
0193-1849/85 $5.00
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AJP - Endocrinology and Metabolism, Vol 248, Issue 4 463-E470, Copyright © 1985 by American Physiological Society

ARTICLES

Effect of glucagon on hepatic lactate metabolism in the conscious dog

M. A. Davis, P. E. Williams and A. D. Cherrington

The present experiments were undertaken to assess hepatic lactate metabolism in the overnight-fasted, conscious dog after a physiological elevation in glucagon. Animals were given somatostatin plus intraportal insulin (243 microU . kg-1 . min-1) and glucagon (0.65 ng . kg-1 . min-1) to initially fix the pancreatic hormone levels at basal values. After a 40-min control period the glucagon level was increased to 527 +/- 27 pg/ml, while the insulin level was left unchanged (10 microU/ml). Fifteen minutes later blood lactate had increased by 215 +/- 24 mumol/l because of a marked increase in lactate output by the liver [2.4 +/- 2.0 to 10.0 +/- 3.8 mumol . kg . min (P less than 0.05)]. Subsequently, hepatic lactate output decreased, and after 3 h the liver was taking up lactate at a rate of 3.1 +/- 1.6 mumol . kg-1 . min-1 (P less than 0.05). Gut and renal lactate production were not significantly affected by glucagon. The rate of conversion of lactate and alanine to glucose had tripled after 3 h of hyperglucagonemia, while the efficiency with which the liver converted the incoming gluconeogenic precursors to glucose had doubled. The fractional extraction of alanine by the liver had more than doubled by 3 h, and net hepatic alanine uptake had increased by 50%.(ABSTRACT TRUNCATED AT 250 WORDS)


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