AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 248: E363-E369, 1985;
0193-1849/85 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Laszewski, B.
Right arrow Articles by Ruff, R. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Laszewski, B.
Right arrow Articles by Ruff, R. L.

AJP - Endocrinology and Metabolism, Vol 248, Issue 3 363-E369, Copyright © 1985 by American Physiological Society

ARTICLES

Effects of glucocorticoid treatment on excitation-contraction coupling

B. Laszewski and R. L. Ruff

We studied the myofibrillar calcium affinity and mechanical threshold of single muscle fibers from the extensor digitorum longus (EDL) and soleus muscles of male Sprague-Dawley rats treated with daily intramuscular injections of dexamethasone, 1.5 mg/kg, for 14 days. The strength-duration and pCa-tension relationships of EDL fibers were not altered by glucocorticoid treatment. However, in soleus fibers the mechanical threshold was increased and the myofibrillar calcium sensitivity was reduced by dexamethasone treatment. Glucocorticoid treatment did not change the maximum tension per cross-sectional area of single-skinned EDL or soleus fibers. The glucocorticoid-induced atrophy and impaired force-generating capacity of fast-twitch muscle are probably not caused by impaired excitation-contraction coupling.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
L. M. Schwartz and R. L. Ruff
Changes in contractile properties of skeletal muscle during developmentally programmed atrophy and death
Am J Physiol Cell Physiol, June 1, 2002; 282(6): C1270 - C1277.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online