| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Endocrinology and Metabolism, Vol 247, Issue 6 726-E731, Copyright © 1984 by American Physiological Society
ARTICLES |
T. Ploug, H. Galbo and E. A. Richter
We reinvestigated the prevailing concept that muscle contractions only elicit increased muscle glucose uptake in the presence of a so-called "permissive" concentration of insulin (Berger et al., Biochem. J. 146: 231-238, 1975; Vranic and Berger, Diabetes 28: 147-163, 1979). Hindquarters from rats in severe ketoacidosis were perfused with a perfusate containing insulin antiserum. After 60 min perfusion, electrical stimulation increased glucose uptake of the contracting muscles fivefold. Also, subsequent contractions increased glucose uptake in hindquarters from nondiabetic rats perfused for 1.5 h in the presence of antiserum. 3-O-methylglucose uptake was increased markedly by contractions in fast-twitch red and white fibers that were severely glycogen depleted but not in slow-twitch red fibers that were not glycogen depleted. In hindquarters from ketoacidotic rats perfused exactly as by Berger et al., 3-O-methylglucose uptake increased during contractions and glucose uptake was negative at rest and zero during contractions. An increase in muscle transport and uptake of glucose during contractions does not require the presence of insulin. Furthermore, glucose transport in contracting muscle may only increase if glycogen is depleted.
This article has been cited by other articles:
|
|
 |
|
  J. O. Holloszy Exercise-induced increase in muscle insulin sensitivity J Appl Physiol, July 1, 2005; 99(1): 338 - 343. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hamada, H. Sasaki, T. Hayashi, T. Moritani, and K. Nakao Enhancement of whole body glucose uptake during and after human skeletal muscle low-frequency electrical stimulation J Appl Physiol, June 1, 2003; 94(6): 2107 - 2112. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Kingwell, M. Formosa, M. Muhlmann, S. J. Bradley, and G. K. McConell Nitric Oxide Synthase Inhibition Reduces Glucose Uptake During Exercise in Individuals With Type 2 Diabetes More Than in Control Subjects Diabetes, August 1, 2002; 51(8): 2572 - 2580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. P. Wojtaszewski, J. N. Nielsen, and E. A. Richter Exercise Effects on Muscle Insulin Signaling and Action: Invited Review: Effect of acute exercise on insulin signaling and action in humans J Appl Physiol, July 1, 2002; 93(1): 384 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ai, J. Ihlemann, Y. Hellsten, H. P. M. M. Lauritzen, D. G. Hardie, H. Galbo, and T. Ploug Effect of fiber type and nutritional state on AICAR- and contraction-stimulated glucose transport in rat muscle Am J Physiol Endocrinol Metab, June 1, 2002; 282(6): E1291 - E1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Jakobsen, D. G. Hardie, N. Morrice, and H. E. Tornqvist 5'-AMP-activated Protein Kinase Phosphorylates IRS-1 on Ser-789 in Mouse C2C12 Myotubes in Response to 5-Aminoimidazole-4-carboxamide Riboside J. Biol. Chem., December 7, 2001; 276(50): 46912 - 46916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. R. Bruce, J. S. Lee, and J. A. Hawley Postexercise muscle glycogen resynthesis in obese insulin-resistant Zucker rats J Appl Physiol, October 1, 2001; 91(4): 1512 - 1519. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gaster, P. Staehr, H. Beck-Nielsen, H. D. Schrøder, and A. Handberg GLUT4 Is Reduced in Slow Muscle Fibers of Type 2 Diabetic Patients: Is Insulin Resistance in Type 2 Diabetes a Slow, Type 1 Fiber Disease? Diabetes, June 1, 2001; 50(6): 1324 - 1329. [Abstract] [Full Text]
|
|
|
|
|
|
P. Peltoniemi, H. Yki-Järvinen, V. Oikonen, A. Oksanen, T. O. Takala, T. Rönnemaa, M. Erkinjuntti, M. J. Knuuti, and P. Nuutila Resistance to Exercise-Induced Increase in Glucose Uptake During Hyperinsulinemia in Insulin-Resistant Skeletal Muscle of Patients With Type 1 Diabetes Diabetes, June 1, 2001; 50(6): 1371 - 1377. [Abstract] [Full Text]
|
|
|
|
|
|
G. P. Pappas, E. W. Olcott, and J. E. Drace Imaging of skeletal muscle function using 18FDG PET: force production, activation, and metabolism J Appl Physiol, January 1, 2001; 90(1): 329 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Greiwe, J. O. Holloszy, and C. F. Semenkovich Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signaling J Appl Physiol, July 1, 2000; 89(1): 176 - 181. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Niklasson, P. Daneryd, P. Lonnroth, and A. Holmang Effects of exercise on insulin distribution and action in testosterone-treated oophorectomized female rats J Appl Physiol, June 1, 2000; 88(6): 2116 - 2122. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Reynolds IV, J. T. Brozinick Jr., L. M. Larkin, and S. W. Cushman Transient enhancement of GLUT-4 levels in rat epitrochlearis muscle after exercise training J Appl Physiol, June 1, 2000; 88(6): 2240 - 2245. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gaster, P. Poulsen, A. Handberg, H. D. Schroder, and H. Beck-Nielsen Direct evidence of fiber type-dependent GLUT-4 expression in human skeletal muscle Am J Physiol Endocrinol Metab, May 1, 2000; 278(5): E910 - E916. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Farrell, M. J. Fedele, J. Hernandez, J. D. Fluckey, J. L. Miller III, C. H. Lang, T. C. Vary, S. R. Kimball, and L. S. Jefferson Hypertrophy of skeletal muscle in diabetic rats in response to chronic resistance exercise J Appl Physiol, September 1, 1999; 87(3): 1075 - 1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ihlemann, T. Ploug, Y. Hellsten, and H. Galbo Effect of tension on contraction-induced glucose transport in rat skeletal muscle Am J Physiol Endocrinol Metab, August 1, 1999; 277(2): E208 - E214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bergeron, R. R. Russell III, L. H. Young, J.-M. Ren, M. Marcucci, A. Lee, and G. I. Shulman Effect of AMPK activation on muscle glucose metabolism in conscious rats Am J Physiol Endocrinol Metab, May 1, 1999; 276(5): E938 - E944. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. T. Brozinick Jr. and M. J. Birnbaum Insulin, but Not Contraction, Activates Akt/PKB in Isolated Rat Skeletal Muscle J. Biol. Chem., June 12, 1998; 273(24): 14679 - 14682. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. H. Reynolds IV, J. T. Brozinick Jr., M. A. Rogers, and S. W. Cushman Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen Am J Physiol Endocrinol Metab, May 1, 1998; 274(5): E773 - E778. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. H. Host, P. A. Hansen, L. A. Nolte, M. M. Chen, and J. O. Holloszy Rapid reversal of adaptive increases in muscle GLUT-4 and glucose transport capacity after training cessation J Appl Physiol, March 1, 1998; 84(3): 798 - 802. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Hayashi, J. F. P. Wojtaszewski, and L. J. Goodyear Exercise regulation of glucose transport in skeletal muscle Am J Physiol Endocrinol Metab, December 1, 1997; 273(6): E1039 - E1051. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
