AJP - Endocrinology and Metabolism, Vol 247, Issue 3 398-E404, Copyright © 1984 by American Physiological Society
Adrenocorticotropin response to graded blood loss in the cat
D. A. Bereiter, A. M. Zaid and D. S. Gann
To assess the early endocrine and physiological responses to rapid blood
loss, adult cats anesthetized with chloralose-urethan sustained transient
hemorrhage (H) of different magnitudes for a 3-min duration. The magnitude
of H was expressed as a percentage of initial total blood volume after
plasma volume determination by dye dilution or on a per unit body weight
basis. Considerable variation in total blood volume was observed at all
body weights (range, 44.5-80.2 mg/kg). Adrenocorticotropin (ACTH) in
peripheral venous plasma was not significantly altered by 10% H but
increased modestly after 20% H by 5 min (148 +/- 67 pg/ml) and rose
promptly after 30% H by 2 min (541 +/- 155 pg/ml) with a peak at 5 min (579
+/- 171 pg/ml). Total change in ACTH during the 15-min sampling period was
proportional to the magnitude of H (r = 0.730, P less than 0.001). Mean
arterial pressure (MAP) decreased significantly to all magnitudes of H by 1
min with a graded recovery during the 3-min hypovolemic period that was
well correlated (r = 0.602, P less than 0.005) with the percentage of blood
volume removed. Mean plasma glucose concentration was not significantly
changed by 10 or 20% H but increased after 30% H by 5 min (46.2 +/- 10.2
mg/dl). Total glucose change from prestimulus levels during the 15-min
sampling period was correlated with the magnitude of H (r = 0.731, P less
than 0.001). Plasma norepinephrine increased equally after 20 or 30% H or
10 ml/kg H but was not significantly elevated after 10% H.(ABSTRACT
TRUNCATED AT 250 WORDS)
