AJP - Endo Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 247: E355-E361, 1984;
0193-1849/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Quillen, E. W.
Right arrow Articles by Cowley, A. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Quillen, E. W., Jr
Right arrow Articles by Cowley, A. W., Jr

AJP - Endocrinology and Metabolism, Vol 247, Issue 3 355-E361, Copyright © 1984 by American Physiological Society

ARTICLES

Osmotic control of vasopressin with chronically altered volume states in anephric dogs

E. W. Quillen Jr, M. M. Skelton, J. Rubin and A. W. Cowley Jr

Continuous peritoneal dialysis has been used to maintain anephric dogs at chronically sustained low, normal, and high volume states in order to study the long-term interaction of volume and osmotic stimuli in the control of plasma vasopressin (PAVP). Bilaterally nephrectomized dogs were maintained for 1-3 mo with normal plasma sodium and potassium levels and blood urea nitrogen of 70.1 +/- 10.8 mg/dl. During the first month, the dogs were dialysized to each of the three volume states. After each volume state had been maintained for 7 days, an osmotic forcing with intravenous distilled H2O and hypertonic NaCl was performed in the conscious state to quantitate the relationship between plasma osmolality (Posm) and PAVP. During the osmotic forcings left atrial pressure (LAP) averaged -2.4 +/- 0.5, 2.6 +/- 0.8, and 11.9 +/- 1.1 cmH2O; mean arterial pressure averaged 113 +/- 11, 125 +/- 10, and 148 +/- 8 mmHg, both respective for the low, normal, and high volume states. The slope of the normovolemic Posm-PAVP relationship was determined to be 0.047 pg X ml-1 X mosmol-1 X kg-1, and neither the hypovolemic or hypervolemic relationships were significantly different. The results demonstrate two additional points that must be considered in the control of PAVP. First, the severely depressed sensitivity of osmotic PAVP control suggests that either the dialysis procedures or the absence of the kidneys suppressed or eliminated some factor normally important to the secretion of vasopressin.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
M. Hayashi, H. Arima, M. Goto, R. Banno, M. Watanabe, I. Sato, H. Nagasaki, and Y. Oiso
Vasopressin gene transcription increases in response to decreases in plasma volume, but not to increases in plasma osmolality, in chronically dehydrated rats
Am J Physiol Endocrinol Metab, February 1, 2006; 290(2): E213 - E217.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. Kondo, H. Arima, R. Banno, S. Kuwahara, I. Sato, and Y. Oiso
Osmoregulation of vasopressin release and gene transcription under acute and chronic hypovolemia in rats
Am J Physiol Endocrinol Metab, March 1, 2004; 286(3): E337 - E346.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online