AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 247: E130-E135, 1984;
0193-1849/84 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ellis, G. B.
Right arrow Articles by Desjardins, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ellis, G. B.
Right arrow Articles by Desjardins, C.

AJP - Endocrinology and Metabolism, Vol 247, Issue 1 130-E135, Copyright © 1984 by American Physiological Society

ARTICLES

Mapping episodic fluctuations in plasma LH in orchidectomized rats

G. B. Ellis and C. Desjardins

Reports of the frequency of pulsatile LH release in orchidectomized rats are surprisingly variable. Estimates of the period between LH pulses vary from 18.5 to 250 min in nine reports from six laboratories, published in 1981-1983. In these studies, blood samples were drawn at intervals ranging from 2.5 to 60 min. We examined the relationship between estimated LH pulse frequency and blood-sampling interval. Six castrated male rats were cannulated, and blood samples were drawn at 2.5-min intervals through 4 h. Plasma LH levels were determined by radioimmunoassay. Using the data obtained at 2.5-min intervals, we simulated blood-sampling intervals of 5, 7.5, 10, 12.5, and 15 min by sequentially deleting data points. The original and simulated data sets were analyzed by both the PULSAR and Cycle Detector computer programs. The results show that as the sampling interval increased from 2.5 to 15 min, the apparent period of pulsatile LH release rose steadily from about 20 min to about 100 min. We found a high, positive correlation between blood-sampling interval and the apparent period of LH pulses. Estimates of LH pulse frequency in castrated male rats vary directly with the frequency at which blood samples are taken. Sampling intervals greater than 5 min in orchidectomized rats yield an LH pulse period that is most likely exaggerated.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
D. D. Pierroz, A. C. Aebi, I. T. Huhtaniemi, and M. L. Aubert
Many LH peaks are needed to physiologically stimulate testosterone secretion: modulation by fasting and NPY
Am J Physiol Endocrinol Metab, April 1, 1999; 276(4): E603 - E610.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online