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Am J Physiol Endocrinol Metab 246: E516-E518, 1984;
0193-1849/84 $5.00
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AJP - Endocrinology and Metabolism, Vol 246, Issue 6 516-E518, Copyright © 1984 by American Physiological Society

ARTICLES

Effects of ammonium chloride on resorption of fetal rat bones in organ culture

A. J. Johannesson and L. G. Raisz

Ammonium chloride, a known inhibitor of lysosomal function, was found to be a rapid and potent inhibitor of 45Ca release from fetal rat bones in organ culture. The response to parathyroid hormone and prostaglandin E2 was inhibited in a dose-related, reversible fashion. The activity of the lysosomal enzyme beta-glucuronidase in the medium closely paralleled 45Ca release. Ammonium chloride may now be added to the list of antilysosomal agents that inhibit bone resorption in vitro.




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