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Am J Physiol Endocrinol Metab 246: E306-E310, 1984;
0193-1849/84 $5.00
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AJP - Endocrinology and Metabolism, Vol 246, Issue 4 306-E310, Copyright © 1984 by American Physiological Society

ARTICLES

Aldosterone blocks adrenal compensatory hypertrophy in the rat

W. E. Grizzle and N. E. Dunlap

We report that adrenal compensatory hypertrophy occurs in intact and hypophysectomized anesthetized rats as well as in rats in which endogenous ACTH is suppressed by administration of dexamethasone or of dexamethasone plus low-dose ACTH. However, adrenal compensatory hypertrophy is blocked in intact and hypophysectomized animals when aldosterone alone or the combination of aldosterone, dexamethasone, and ACTH is administered using Alzet pumps. These data support previous reports that questioned the validity of the hypothesis that adrenal compensatory hypertrophy is controlled by the glucocorticoid-ACTH negative feedback system. These results require modification of current hypotheses concerning the mechanism of adrenal compensatory hypertrophy to allow for a central nervous system or other effect of aldosterone.


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W. C. Engeland, W. B. Ennen, A. Elayaperumal, D. A. Durand, and B. K. Levay-Young
Zone-specific cell proliferation during compensatory adrenal growth in rats
Am J Physiol Endocrinol Metab, February 1, 2005; 288(2): E298 - E306.
[Abstract] [Full Text] [PDF]


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