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Am J Physiol Endocrinol Metab 246: E266-E270, 1984;
0193-1849/84 $5.00
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AJP - Endocrinology and Metabolism, Vol 246, Issue 3 266-E270, Copyright © 1984 by American Physiological Society

ARTICLES

Effect of age and dietary calcium on renal 25(OH)D metabolism, serum 1,25(OH)2D, and PTH

H. J. Armbrecht, L. R. Forte and B. P. Halloran

The purpose of this study was to determine how serum 1,25(OH)2D, renal production of [3H]1,25(OH)2D and [3H]24,25(OH)2D from [3H]25(OH)D, and serum IPTH change with age and dietary Ca restriction. Male Fischer 344 rats aged 3, 13, and 25 mo were placed on either a high-Ca (1.2%) or low-Ca (0.02%) vitamin D-replete diet. After 4 wk, serum was collected, and renal conversion of [3H]25(OH)D3 to [3H]1,25(OH)2D3 and [3H]24,25(OH)2D3 was measured in vitro using isolated renal cortical slices. Serum 1,25(OH)2D and renal [3H]1,25(OH)2D3 production were markedly reduced in 13- and 25-mo-old rats compared with 3-mo-old rats fed the low-Ca diet. In 3-mo-old rats, feeding the low-Ca diet increased serum 1,25(OH)2D by 18-fold and renal [3H]1,25(OH)2D3 production by threefold compared with feeding the high-Ca diet. In 25-mo-old rats, dietary Ca had no effect on these parameters. Renal [3H]24,25(OH)2D3 production was increased in the 13- and 25-mo-old rats compared with the 3-mo-old rats. Serum IPTH increased with age regardless of diet and was significantly increased by the low-Ca diet in 3-mo but not in 13- or 25-mo-old rats. The changes in serum 1,25(OH)2D and renal [3H]1,25(OH)2D3 production observed in this study may account for the previously observed age-related decline in intestinal Ca absorption in this animal model.


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