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Am J Physiol Endocrinol Metab 246: E129-E133, 1984;
0193-1849/84 $5.00
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AJP - Endocrinology and Metabolism, Vol 246, Issue 2 129-E133, Copyright © 1984 by American Physiological Society

ARTICLES

Influence of converting-enzyme inhibition on rat des-angiotensin I-angiotensinogen

E. Clauser, J. Bouhnik, M. F. Gonzalez, P. Corvol and J. Menard

The effects of high plasma renin levels on plasma levels of both total immunoreactive angiotensinogen (direct radioimmunoassay) and intact angiotensinogen measured by angiotensin I released by renin (indirect assay) were studied in sodium-depleted rats both with and without captopril treatment and in adrenalectomized rats. The direct assay measures both intact angiotensinogen and des-angiotensin I-angiotensinogen, its residue cleaved by renin. The indirect assay measures only intact angiotensinogen. Neither sodium depletion, captopril treatment, nor adrenalectomy modified the circulating levels of total angiotensinogen. However these treatments produced a decrease in intact angiotensinogen that was in proportion to the elevation of renin levels. The difference between the two assays for angiotensin represents the level of des-angiotensin I-angiotensinogen and correlated satisfactorily with the plasma levels of renin. Identical correlations were observed in adrenalectomized rats and captopril-treated rats. We conclude that des-angiotensin I-angiotensinogen levels are an index of activation of the renin-angiotensin system dependent on the circulating level of renin.


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