AJP - Endo Watch the video to learn how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 244: E425-E429, 1983;
0193-1849/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Curry, D. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Curry, D. L.

AJP - Endocrinology and Metabolism, Vol 244, Issue 4 425-E429, Copyright © 1983 by American Physiological Society

ARTICLES

Direct tonic inhibition of insulin secretion by central nervous system

D. L. Curry

An experimental animal model was developed to investigate the influence of the central nervous system (CNS) on insulin secretion via direct innervation to the pancreas. This model eliminates any indirect CNS effect on the pancreas by hormonal factors. It consists of a vascularly isolated, in situ perfused rat pancreas preparation with the cephalic portion of the animal functional, including innervation to the pancreas. Using this rat model, we have demonstrated that the nonstimulated rat brain exerts a tonic inhibition of glucose-stimulated insulin secretion in nonfasted rats. This inhibition can only occur directly via neurons from brain to pancreas, probably via the sympathetic nervous system. The brain does not alter the biphasic pattern of insulin secretion, but it suppresses the overall insulin secretory process throughout both phases of insulin secretion by a relatively constant degree ranging from 38 to 47%. The physiological purpose of this tonic suppression of insulin secretion is open to speculation, but it is well known that tonic sympathetic stimulation of the cardiovascular system represents an important physiological control mechanism. An analogous control may exist with respect to insulin secretion.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
S. Blat and C. H. Malbert
The vagus is inhibitory of insulin secretion under fasting conditions
Am J Physiol Endocrinol Metab, October 1, 2001; 281(4): E782 - E788.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online