AJP - Endocrinology and Metabolism, Vol 244, Issue 2 141-E144, Copyright © 1983 by American Physiological Society
Inhibition of bone resorption in tissue culture by H1-receptor antagonists
P. Goldhaber and L. Rabadjija
Mouse bone culture studies show that several representative H1-receptor
antagonists, promethazine hydrochloride, pyrilamine maleate, tripelennamine
hydrochloride, and diphenhydramine hydrochloride, inhibit parathyroid
extract-stimulated bone resorption. The H2-receptor antagonists, metiamide
and cimetidine, are ineffective. In view of the finding that histamine and
histamine agonists did not stimulate bone resorption, it is unlikely that
histamine receptors are involved in mediating parathyroid
extract-stimulated bone resorption. Because H1-receptor antagonists bind to
phospholipids and have been shown to influence membrane structure and
function, it is suggested that they inhibit bone resorption by a mechanism
that depends on their membrane-stabilizing effect.
