AJP - Endocrinology and Metabolism, Vol 243, Issue 5 360-E364, Copyright © 1982 by American Physiological Society
Decreased rate of protein breakdown during nutritional recovery of mouse kidney
J. A. Bur and R. D. Conde
After a 5-day protein-depletion diet, there is a 23% decrease in kidney
protein content in mice. When mice are shifted to a normal diet, protein
mass is restored to its normal value 15 h after the nutritional change. The
mechanism for this protein-depleted mice have a protein synthesis
efficiency in vivo equal to 71% of that in normal kidneys, and normal
values were reached within 6 h after the nutritional shift; 2) protein
degradation rates were estimated either from the difference between the
synthesis of kidney proteins and the net protein increase or by the
disappearance of radioactivity from kidney proteins previously labeled by
the administration of NaH14CO3 to mice. By both procedures, a large
decrease in protein degradation rates during the recovery through a
complete diet was observed.
