AJP - Endocrinology and Metabolism, Vol 243, Issue 3 213-E216, Copyright © 1982 by American Physiological Society
Central control of peripheral circulating somatostatin in dogs: effect of 2-deoxyglucose
E. Ipp, U. Piran, H. Richter, C. Garberoglio, A. Moossa and A. H. Rubenstein
Circulating plasma somatostatin concentrations are known to fluctuate in
response to nutrients and hormones. However, little is known about neural
or central nervous system (CNS) control of somatostatin secretion. To test
whether peripheral circulating somatostatin is influenced by a central
stimulus, 2-deoxyglucose (37.5 mg/kg) was infused into a lateral cerebral
ventricle of six conscious dogs over a period of 15 min. Plasma
somatostatin levels rose from a base line of 105 +/- 6 pg/ml (mean +/- SE)
to a peak of 154 +/- 10 pg/ml (P less than 0.005) at 30 min after the onset
of the infusion. Somatostatin levels were still significantly elevated (P
less than 0.025) at 60 min (119 +/- 6 pg/ml) and thereafter gradually
returned toward base line. Plasma glucose and glucagon levels increased in
response to intraventricular 2-deoxyglucose. Glucose concentrations rose
from 105 +/- 5 mg/dl to peak at 203 +/- 16 mg/dl (P less than 0.005) at 80
min and remained elevated to 120 min. The concentration of plasma glucagon
increased from 41 +/- 6 to 92 +/- 18 pg/ml at 60 min (P less than 0.05) and
then declined. In marked contrast to intraventricular 2-deoxyglucose,
similar concentrations of 2-deoxyglucose administered intravenously (n = 4)
resulted in a slight fall in plasma somatostatin. Intraventricular saline
did not result in a change in plasma somatostatin. It is concluded that
peripheral circulating somatostatin may be susceptible to central nervous
system control.
