AJP - Endocrinology and Metabolism, Vol 242, Issue 1 53-E58, Copyright © 1982 by American Physiological Society
Effects of amino acids and gastric inhibitory polypeptide on insulin release in dogs
J. G. Yovos, T. M. O'Dorisio, T. N. Pappas, S. Cataland, F. B. Thomas, H. Mekhjian and L. C. Carey
Insulin release following intravenous administration of an amino acid
solution with and without a simultaneous infusion of varying amounts of
porcine gastric inhibitory polypeptide (GIP) was studied in dogs. Group I
received a 10-amino acid mixture (300 mosmol/kg iv) at 16.6 ml/min for 1 h;
group II, amino acid mixture plus 0.5 micrograms.kg-1.h-1 porcine GIP;
group III, amino acid mixture plus 1.0 micrograms.kg-1.h-1 of GIP; group IV
(a and b) received either 0.5 or 1.0 micrograms.kg-1.h-1 of GIP alone.
Compared to group I, groups II and III had a greater insulin response
during the first 30 min of the infusion. Group] IV (a and b) showed no
insulin release. Glucose concentrations showed no significant change in all
groups. From these results, it is concluded that insulin release after
intravenous infusion of an amino acid mixture plus GIP is greater than
after amino acids or GIP alone. It appears that this effect is more
pronounced in the early phase of insulin release.
