AJP - Endocrinology and Metabolism, Vol 240, Issue 3 274-E278, Copyright © 1981 by American Physiological Society
Effect of catecholamines on somatostatin secretion by isolated perfused rat stomach
Y. Goto, M. Berelowitz and L. A. Frohman
The secretion of somatostatin-like immunoreactivity (SRIF-LI) by the
isolated perfused rat stomach was studied in response to stimulation by
catecholamines. Gastric SRIF-LI secretion was significantly stimulated in a
dose-dependent manner by norepinephrine at 10(-6) and 10(-8) M, and the
effect of norepinephrine (10(-8) M) was attenuated by the addition of
propranolol (10(-6) M) but not of phentolamine (10(-6) M). SRIF-LI
secretion was also stimulated by dopamine at concentrations of 10(-4) and
10(-6) M but not at 10(-8) M. The effect of dopamine (10(-6) M) was not
altered by the addition of haloperidol (10(-4) to 10(-7)) or metoclopramide
(10(-4) M), and bromocriptine (10(-6) M) was without effect on SRIF-LI
secretion. These results suggest that gastric SRIF-LI secretion is
stimulated by a beta-adrenergic mechanism and raise the possibility that
gastric somatostatin contributes to the inhibitory effect of norepinephrine
on gastric acid secretion.
