AJP - Endocrinology and Metabolism, Vol 239, Issue 5 311-E316, Copyright © 1980 by American Physiological Society
Increased muscle glucose uptake and lactate release after endotoxin administration
A. J. Romanosky, G. J. Bagby, E. L. Bockman and J. J. Spitzer
Changes in glucose uptake and lactate and alanine release by skeletal
muscle were studied in anesthetized dogs before and over a 4-h period after
endotoxin administration and in time-matched controls. Blood flow was
measured directly, and arteriovenous differences of glucose, lactate,
alanine, and O2 were determined in hindlimb muscles by obtaining blood
samples simultaneously from the carotid artery and profunda femoris veins.
Skeletal muscle blood flow decreased by 29% after endotoxin, reflecting a
similar average decrease in cardiac output. Mean arterial glucose decreased
31% and arterial lactate and alanine increased 201 and 123%, respectively,
after endotoxin administration. Skeletal muscle glucose uptake increased
57% after endotoxin despite the progressively developing hypoglycemia.
Postendotoxin lactate and alanine release were also elevated by 217 and
82%, respectively. Average O2 consumption by skeletal muscle did not
change. The metabolic pattern observed after endotoxin administration
suggests that the increased lactate and alanine release are likely to be
related to the elevated glucose uptake and that skeletal muscle greatly
influences the metabolic pattern observed during shock.
