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Am J Physiol Endocrinol Metab 239: E162-E167, 1980;
0193-1849/80 $5.00
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AJP - Endocrinology and Metabolism, Vol 239, Issue 2 162-E167, Copyright © 1980 by American Physiological Society

ARTICLES

Hormonal modulation of adipose tissue lipoprotein lipase may alter food intake in rats

L. Steingrimsdottir, J. Brasel and M. R. Greenwood

Daily injections of 5 mg progesterone for 3 wk preferentially increased parametrial depot weight and fat cell size in ovarian intact rats. Adipose tissue lipoprotein lipase (LPL) activity was also preferentially increased in the parametrial depot. LPL activity increased at 24 h, whereas food intake did not increase until 36 h after the first injection. Parametrial fat cell size was significantly increased by 84 h and increased further by 3 wk. Daily injections of 2.5 microgram of estradiol for 3 wk decreased fat cell size and LPL activity in the parametrial depot of female rats, whereas in vitro glycerol release was unchanged. Serum triglycerides were increased, but free fatty acids were unaffected. The data suggest that ovarian hormones affected fat cell size in the rat through their modulation of LPL activity. These findings are consistent with the hypothesis that, during progesterone administration, preferential uptake of serum triglycerides into adipose stores decreases the availability of triglyceride-derived energy to the organism stimulating increased food intake.


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