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Am J Physiol Endocrinol Metab 238: E540-E542, 1980;
0193-1849/80 $5.00
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AJP - Endocrinology and Metabolism, Vol 238, Issue 6 540-E542, Copyright © 1980 by American Physiological Society

ARTICLES

Leucogenenol a thymothyroid hormone

F. A. Rice, J. D. McCurdy and C. Oresajo

Thymectomy and, to a lesser extent, thyroidectomy cause a significant decrease in the serum leucogenenol levels of rats. Daily injections of neonatally thymectomized mice with leucogenenol causes the mice to maintain a normal level of neutrophils and lymphocytes in their circulation. The thymus and thyroid are the only tissues in rats and mice that afford radioactive leucogenenol when incubated in a medium containing radioactive D-glucose. It is concluded that the thymus and possibly the thyroid are responsible for the normal biosynthesis of leucogenenol in animals.




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