AJP - Endo AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Endocrinol Metab 238: E307-E312, 1980;
0193-1849/80 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Danguir, J.
Right arrow Articles by Nicolaidis, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Danguir, J.
Right arrow Articles by Nicolaidis, S.

AJP - Endocrinology and Metabolism, Vol 238, Issue 4 307-E312, Copyright © 1980 by American Physiological Society

ARTICLES

Intravenous infusions of nutrients and sleep in the rat: an ischymetric sleep regulation hypothesis

J. Danguir and S. Nicolaidis

Unrestrained food-deprived rats received their daily caloric needs through continuous or discontinuous intravenous infusions of specific nutritive substances over a period of 3 consecutive days each, and the effect on sleep monitored by electroencephalogram was examined. Continuous glucose or lipid infusions did not affect the daily sleep quotas. Amino-acid infusion brought about a significant increase in paradoxical sleep (PS), whereas slow-wave sleep (SWS) remained unchanged. Rats that received the highly nutritive composite solution showed significant increase in both SWS and PS. The same increase in SWS and PS was observed when exogenous insulin was coinfused with continuous infusion of glucose or when glucose infusions were discontinuous. These findings suggest that sleep might be related to both the nature and the degree of utilization of the circulating metabolites. A model for the action on sleep of nutrients at the systemic level was proposed; only when substances are metabolized is there a direct effect on sleep mechanisms.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. K. Hansen, L. Kapas, J. Fang, and J. M. Krueger
Cafeteria diet-induced sleep is blocked by subdiaphragmatic vagotomy in rats
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R168 - R174.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online