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Am J Physiol Endocrinol Metab 238: E284-E292, 1980;
0193-1849/80 $5.00
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AJP - Endocrinology and Metabolism, Vol 238, Issue 3 284-E292, Copyright © 1980 by American Physiological Society

ARTICLES

Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia

M. P. Cleary, J. R. Vasselli and M. R. Greenwood

The free-feeding, genetically obese rat is hyperphagic, hyperinsulinemic, and hypertriglyceridemic and has increased fat cell size and number compared to its lean littermate. These experiments demonstrate that, when fafa rats are prevented from expressing hyperphagia throughout life, the complete obese "syndrome" still develops. Furthermore, life-long food restriction does not prevent increased lipoprotein lipase in the fafa rat. The data support the concept that a peripheral metabolic adaptation, probably in lipid metabolism, results in preferential shunting of dietary substrate in the restricted obese rats to adipose tissue with concomitant decreases in other tissues.


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