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Am J Physiol Endocrinol Metab 234: E204-E208, 1978;
0193-1849/78 $5.00
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AJP: Endocrinology and Metabolism, Vol 234, Issue 2, E204-E208
Copyright © 1978 by American Physiological Society

ARTICLES

Effects of endogenous prostaglandin E on intestinal motility

KM Sanders and G Ross

The role of endogenous prostaglandin E (PGE) in the regulation of intestinal motility in situ was studied in cats anesthetized with pentobarbital. The basal concentration of PGE in the ileum was found by radioimmunoassay to be 3.3 +/- 0.6 ng PGE per g wet wt (chi +/- SE, n = 12). Intramesenteric arterial infusion of acetylcholine (ACh) (100 microgram/min) increased intestinal motility, and PGE concentration rose to 6.7 +/- 0.8 ng/g. Intravenous infusion of indomethacin (4 mg/kg) enhanced spontaneous and ACh-induced motility and abolished the ACh-induced rise in ileal PGE concentration. We conclude that basal PGE synthesis limits the motility of the resting and ACh-stimulated cat ileum.




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