Table  2.   MRI measurements at baseline and after 12 mo of cross-sex hormone administration in M-F and F-M transsexuals


M-F Transsexuals
F-M Transsexuals
Baseline After 12 mo 95% CI of difference P value Baseline After 12 mo 95% CI of difference P value

Subcutaneous fat, cm2
  Abdomen 87 ± 43  137 ± 52  (39; 61) <0.001 164 ± 90  136 ± 71  (-45; -10) <0.01
  Hip 91 ± 48  151 ± 49  (48; 73) <0.001 175 ± 70  129 ± 54  (-57; -35) <0.001
  Thigh 123 ± 58  204 ± 57  (64; 96) <0.001 244 ± 78  188 ± 61  (-69; -42) <0.001
Visceral fat, cm2 40 ± 19  47 ± 18  (2; 12) 0.01 39 ± 16  44 ± 19  (2; 9) <0.01
V/S 0.50 ± 0.18  0.37 ± 0.14  (-0.18; -0.07) <0.001 0.27 ± 0.08  0.35 ± 0.10  (0.06; 0.11) <0.001
Muscle area, cm2 307 ± 47  278 ± 37  (-38; -20) <0.001 239 ± 33  285 ± 36  (39; 54) <0.001
Total area, cm2
  Abdomen 374 ± 74  416 ± 87  (24; 60) <0.001 406 ± 110  413 ± 92  (-9; 23) NS
  Hip 538 ± 88  594 ± 95  (42; 69) <0.001 576 ± 110  564 ± 97  (-26; 2) 0.09
  Thigh 441 ± 92  497 ± 93  (36; 76) <0.001 494 ± 102  484 ± 82  (-28; 8) NS
WHR area, cm2/cm2 0.69 ± 0.07  0.70 ± 0.08  (-0.02; 0.03) NS 0.70 ± 0.10  0.73 ± 0.08  (0.00; 0.06) <0.05

Values are means ± SD. CI, confidence interval; V/S, ratio of visceral to subcutaneous abdominal fat area; WHR, waist-to-hip ratio; NS, not significant.